Figure 4.

Exponential decay time constants for hyperpolarized reporter groups in various designed probes, reaching up to several minutes in symmetrically substituted, non-protonated sites. The reported time constants were derived at 9.4 T and 25 °C for ⁸⁹Y-DOTP [28], at 14.1 T and 37 °C for permethylated amino acids [51] and at 14.1 T and 30 °C for choline- and TMPA-based probes [38].