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. 2014 Jan 21;31(3):1067–1078. doi: 10.3892/or.2014.2988

Figure 2.

Figure 2

The distribution of isomiRs and -5p/-3p arm selection in PC3 radiation treatment. (A) Mapping results of hsa-miR-2110. As shown in 5p:8–29, hsa-miR-2110 encodes mature miRNA at only its 5 p arm, and miRNA spans from nucleotide 8 to nucleotide 29 of the hairpin. The integer values on the left denote the read count of each isomiR. The comma-separated values denote the position shift in the isomiR relative to the miRBase annotated positions (8 to 29). The nucleotides in lowercase type denote the sequence fragments originating from the 3′ modification event. (B) The proportion of 3′ modifications at end of reads at different time-points after PC3 radiation treatment as observed from NGS data. (C) Fold-change of the -5p/-3p arm of miRNA at different time points after PC3 radiation treatment as observed from NGS data. isomiRs, miRNA isoforms; miRNA, microRNA; NGS, next-generation sequencing.