Table 2.
Meta-analyses of the association between the 5-HTTLPR polymorphism and the presence of IBS
| |
Ethnicity |
Cases/Controls |
L vs S |
|
|
LL vs SS |
|
|
LL vs LS |
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|
| (OR,95% CI) | P (Model) | Bon | (OR,95% CI) | P (Model) | Bon | (OR,95% CI) | P (Model) | Bon | |||
| IBS |
|
|
|
|
|
|
|
|
|
|
|
| 25 studies |
Overall |
3443/3359 |
(0.993,0.867-1.138) |
P = 0.923 (R) |
1.000 |
(1.009,0.772-1.319) |
P = 0.948 (R) |
1.000 |
(1.284,1.040-1.585) |
P
= 0.020 (R) |
0.120 |
| 11 studies |
Cau/M Cau |
1855/1590 |
(1.008,0.859-1.183) |
P = 0.919 (R) |
1.000 |
(1.018,0.752-1.378) |
P = 0.907 (R) |
1.000 |
(1.288,1.079-1.536) |
P = 0.005 (F) |
0.030 |
| 9 studies |
East Asian |
1138/1102 |
(1.151,0.901-1.471) |
P = 0.261 (R) |
1.000 |
(1.371,0.764-2.461) |
P = 0.291 (R) |
1.000 |
(1.528,0.849-2.751) |
P = 0.157 (R) |
0.942 |
| 1 study |
Turkish |
54/92 |
(0.934,0.577-1.514) |
P = 0.782 |
1.000 |
(0.727,0.271-1.952) |
P = 0.527 |
1.000 |
(0.442,0.171-1.143) |
P = 0.092 |
0.552 |
| 2 studies |
Indian |
301/352 |
(0.687,0.375-1.259) |
P = 0.225 (R) |
1.000 |
(0.588,0.241-1.435) |
P = 0.243 (R) |
1.000 |
(1.077,0.669-1.733) |
P = 0.761 (F) |
1.000 |
| 1 study |
Mexian |
45/123 |
(0.482,0.256-0.910) |
P
= 0.024 |
0.144 |
(0.290,0.082-1.030) |
P = 0.056 |
0.336 |
(0.313,0.073-1.337) |
P = 0.117 |
0.702 |
| 1 study |
Iranian |
50/100 |
(1.083,0.670-1.751) |
P = 0.744 |
1.000 |
(1.168,0.466-2.931) |
P = 0.740 |
1.000 |
(2.246,0.976-5.165) |
P = 0.057 |
1.000 |
| IBS-C |
|
|
|
|
|
|
|
|
|
|
|
| 20 studies |
Overall |
992/2437 |
(1.232,1.048-1.449) |
P
= 0.011 (R) |
0.066 |
(1.570,1.147-2.148) |
P = 0.005 (F) |
0.030 |
(1.658,1.180-2.331) |
P = 0.004 (R) |
0.024 |
| 8 studies |
Cau/M Cau |
462/841 |
(1.270,1.060-1.520) |
P = 0.009 (F) |
0.054 |
(1.627,1.109-2.388) |
P
= 0.013 (F) |
0.078 |
(1.269,0.956-1.685) |
P = 0.100 (F) |
1.000 |
| 8 studies |
East Asian |
393/1052 |
(1.487,1.139-1.941) |
P = 0.003 (R) |
0.018 |
(2.575,1.741-3.808) |
P = 0.000 (F) |
0.000 |
(3.084,2.017-4.715) |
P = 0.000 (F) |
0.000 |
| 1 study |
Turkish |
26/92 |
(0.719,0.379-1.367) |
P = 0.315 |
1.000 |
(0.545,0.156-1.903) |
P = 0.342 |
1.000 |
(0.618,0.172-2.218) |
P = 0.461 |
1.000 |
| 2 studies |
Indian |
96/352 |
(0.798,0.438-1.452) |
P = 0.460 (R) |
1.000 |
(0.676,0.330-1.384) |
P = 0.284 (F) |
1.000 |
(0.769,0.389-1.522) |
P = 0.451 (F) |
1.000 |
| 1 study |
Iranian |
15/100 |
(0.796,0.367-1.725) |
P = 0.563 |
1.000 |
(0.730,0.181-2.951) |
P = 0.659 |
1.000 |
(2.133,0.522-8.714) |
P = 0.291 |
1.000 |
| IBS-D |
|
|
|
|
|
|
|
|
|
|
|
| 21 studies |
Overall |
1454/2813 |
(0.932,0.771-1.126) |
P = 0.466 (R) |
1.000 |
(0.888,0.666-1.183) |
P = 0.416 (R) |
1.000 |
(1.209,0.973-1.502) |
P = 0.086 (R) |
0.516 |
| 9 studies |
Cau/M Cau |
806/1270 |
(0.986,0.863-1.126) |
P = 0.835 (F) |
1.000 |
(0.921,0.706-1.200) |
P = 0.540 (F) |
1.000 |
(1.251,1.005-1.556) |
P
= 0.045 (F) |
0.270 |
| 8 studies |
East Asian |
434/999 |
(0.846,0.694-1.032) |
P = 0.099 (F) |
0.594 |
(0.785,0.498-1.239) |
P = 0.299 (F) |
1.000 |
(0.930,0.579-1.494) |
P = 0.764 (F) |
1.000 |
| 1 study |
Turkish |
18/92 |
(1.087,0.529-2.232) |
P = 0.820 |
1.000 |
(0.324,0.015-7.070) |
P = 0.474 |
1.000 |
(0.046,0.003-0.814) |
P
= 0.036 |
0.216 |
| 2 studies |
Indian |
171/352 |
(0.478,0.084-2.707) |
P = 0.404 (R) |
0.828 |
(0.494,0.069-3.514) |
P = 0.481 (R) |
1.000 |
(1.355,0.715-2.566) |
P = 0.351 (F) |
1.000 |
| 1 study |
Iranian |
25/100 |
(1.325,0.710-2.471) |
P = 0.377 |
1.000 |
(1.565,0.504-4.856) |
P = 0.439 |
1.000 |
(3.333,1.159-9.586) |
P
= 0.025 |
0.150 |
| IBS-M |
|
|
|
|
|
|
|
|
|
|
|
| 17 studies |
Overall |
486/2042 |
(1.087,0.911-1.296) |
P = 0.354 (R) |
1.000 |
(1.170,0.830-1.651) |
P = 0.370 (R) |
1.000 |
(1.313,0.991-1.740) |
P = 0.058 (F) |
0.348 |
| 6 studies |
Cau/M Cau |
265/549 |
(1.096,0.754-1.593) |
P = 0.630 (R) |
1.000 |
(1.153,0.538-2.471) |
P = 0.714 (R) |
1.000 |
(1.533,1.069-2.198) |
P
= 0.020 (F) |
0.120 |
| 7 studies |
East Asian |
167/949 |
(1.030,0.785-1.351) |
P = 0.830 (F) |
1.000 |
(1.135,0.637-2.022) |
P = 0.667 (F) |
1.000 |
(0.906,0.507-1.617) |
P = 0.737 (F) |
1.000 |
| 1 study |
Turkish |
10/92 |
(2.038,0.795-5.225) |
P = 0.138 |
0.828 |
(4.909,0.480-50.178) |
P = 0.180 |
1.000 |
(0.773,0.175-3.415 |
P = 0.734 |
1.000 |
| 2 studies |
Indian |
34/352 |
(1.022,0.616-1.697) |
P = 0.932 (F) |
1.000 |
(1.157,0.452-2.965) |
P = 0.761 (F) |
1.000 |
(1.684,0.662-4.280 |
P = 0.274 (F) |
1.000 |
| 1 study | Iranian | 10/100 | (1.041,0.415-2.610) | P = 0.932 | 1.000 | (1.095,0.141-8.485) | P = 0.931 | 1.000 | (0.889,0.166-4.755 | P = 0.891 | 1.000 |
Cau/M Cau: Caucasian/Mostly Caucasian; F: fixed model; R: random model; Bon: P for Bonferroni adjustment. The significant contrasts were written in bold.