Table 3.
Meta-analyses of the association between the 5-HTTLPR polymorphism and the presence of IBS
| |
Ethnicity |
Cases/Controls |
LS vs SS |
|
|
LL vs LS/SS |
|
|
LL/LS vs SS |
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|
| (OR,95% CI) | P (Model) | Bon | (OR,95% CI) | P (Model) | Bon | (OR,95% CI) | P (Model) | Bon | |||
| IBS |
|
|
|
|
|
|
|
|
|
|
|
| 25 studies |
Overall |
3443/3359 |
(0.814,0.681-0.973) |
P
= 0.023 (R) |
0.138 |
(1.141,0.935-1.391) |
P = 0.195 (R) |
1.000 |
(0.883,0.739-1.055) |
P = 0.171 (R) |
1.000 |
| 11 studies |
Cau/M Cau |
1855/1590 |
(0.796,0.566-1.119) |
P = 0.189 (R) |
1.000 |
(1.506,1.112-2.039) |
P = 0.070 (F) |
0.420 |
(0.874,0.643-1.189) |
P = 0.391 (R) |
1.000 |
| 9 studies |
East Asian |
1138/1102 |
(0.892,0.727-1.094) |
P = 0.272 (R) |
1.000 |
(1.456,0.831-2.549) |
P = 0.189 (R) |
1.000 |
(0.999,0.828-1.207) |
P = 0.995 (F) |
1.000 |
| 1 study |
Turkish |
54/92 |
(1.647,0.774-3.505) |
P = 0.195 |
1.000 |
(0.553,0.227-1.348) |
P = 0.193 |
1.000 |
(1.286,0.636-2.599) |
P = 0.484 |
1.000 |
| 2 studies |
Indian |
301/352 |
(0.542,0.284-1.034) |
P = 0.063 (R) |
0.378 |
(0.763,0.494-1.178) |
P = 0.223 (F) |
1.000 |
(0.555,0.272-1.130) |
P = 0.105 (R) |
1.000 |
| 1 study |
Mexian |
45/123 |
(0.929,0.373-2.316) |
P = 0.875 |
1.000 |
(0.295,0.084-.032) |
P = 0.056 |
0.336 |
(0.581,0.268-1.259) |
P = 0.169 |
1.000 |
| 1 study |
Iranian |
50/100 |
(0.520,0.226-1.197) |
P = 0.124 |
0.744 |
(1.770,0.824-3.803) |
P = 0.143 |
0.858 |
(0.697,0.325-1.495) |
P = 0.354 |
1.000 |
| IBS-C |
|
|
|
|
|
|
|
|
|
|
|
| 20 studies |
Overall |
992/2437 |
(0.926,0.708-1.212) |
P = 0.578 (R) |
1.000 |
(1.545,1.187-2.012) |
P
= 0.001 (R) |
0.006 |
(1.119,0.890-1.406) |
P = 0.335 (R) |
1.000 |
| 8 studies |
Cau/M Cau |
462/841 |
(1.266,0.883-1.815) |
P = 0.199 (F) |
1.000 |
(1.327,1.027-1.715) |
P
= 0.031 (F) |
0.186 |
(1.398,0.994-1.968) |
P = 0.054 (F) |
0.324 |
| 8 studies |
East Asian |
393/1052 |
(0.906,0.672-1.220) |
P = 0.514 (F) |
1.000 |
(2.759,1.933-3.938) |
P
= 0.000 (F) |
0.000 |
(1.250,0.964-1.622) |
P = 0.093 (F) |
0.558 |
| 1 study |
Turkish |
26/92 |
(0.882,0.337-2.307) |
P = 0.799 |
1.000 |
(0.579,0.180-1.860) |
P = 0.358 |
1.000 |
(0.750,0.312-1.803) |
P = 0.165 |
0.990 |
| 2 studies |
Indian |
96/352 |
(0.783,0.185-3.324) |
P = 0.740 (R) |
1.000 |
(0.726,0.378-1.394) |
P = 0.336 (F) |
1.000 |
(0.753,0.213-2.661) |
P = 0.660 (R) |
1.000 |
| 1 study |
Iranian |
15/100 |
(0.342,0.095-1.234) |
P = 0.101 |
0.606 |
(1.368,0.395-4.734) |
P = 0.621 |
1.000 |
(0.448,0.144-1.391) |
P = 0.165 |
0.990 |
| IBS-D |
|
|
|
|
|
|
|
|
|
|
|
| 21 studies |
Overall |
1454/2813 |
(0.863,0.619-1.205) |
P = 0.387 (R) |
1.000 |
(1.042,0.862-1.260) |
P = 0.668 (R) |
1.000 |
(0.885,0.648-1.209) |
P = 0.443 (R) |
1.000 |
| 9 studies |
Cau/M Cau |
806/1270 |
(0.854,0.548-1.332) |
P = 0.423 (R) |
1.000 |
(1.113,0.914-1.357) |
P = 0.286 (F) |
1.000 |
(0.922,0.626-1.357) |
P = 0.680 (R) |
1.000 |
| 8 studies |
East Asian |
434/999 |
(0.896,0.686-1.171) |
P = 0.423 (F) |
1.000 |
(0.850,0.561-1.289) |
P = 0.444 (F) |
1.000 |
(0.843,0.656-1.083) |
P = 0.181 (F) |
1.000 |
| 1 study |
Turkish |
18/92 |
(8.471,1.811-39.626) |
P
= 0.007 |
0.042 |
(0.085,0.005-1.462) |
P = 0.089 |
0.534 |
(5.143,1.115-23.714) |
P
= 0.036 |
0.096 |
| 2 studies |
Indian |
171/352 |
(0.321,0.024-4.370) |
P = 0.394 (R) |
1.000 |
(0.680,0.214-2.159) |
P = 0.513 (F) |
1.000 |
(0.371,0.036-3.819) |
P = 0.405 (R) |
1.000 |
| 1 study |
Iranian |
25/100 |
(0.469,0.152-1.445) |
P = 0.187 |
1.000 |
(2.508,0.986-6.380) |
P = 0.054 |
0.324 |
(0.768,0.286-2.066) |
P = 0.601 |
1.000 |
| IBS-M |
|
|
|
|
|
|
|
|
|
|
|
| 17 studies |
Overall |
486/2042 |
(0.920,0.706-1.199) |
P = 0.538 (F) |
1.000 |
(1.186,0.887-1.584) |
P = 0.250 (R) |
1.000 |
(0.971,0.760-1.242) |
P = 0.817 (F) |
1.000 |
| 6 studies |
Cau/M Cau |
265/549 |
(0.728,0.476-1.112) |
P = 0.142 (F) |
0.852 |
(1.172,0.707-1.942) |
P = 0.539 (R) |
1.000 |
(0.834,0.563-1.237) |
P = 0.368 (F) |
1.000 |
| 7 studies |
East Asian |
167/949 |
(1.106,0.750-1.632) |
P = 0.611 (F) |
1.000 |
(1.000,0.590-1.696) |
P = 1.000 (F) |
1.000 |
(1.082,0.754-1.554) |
P = 0.669 (F) |
1.000 |
| 1 study |
Turkish |
10/92 |
(6.353,0.727-55.545) |
P = 0.095 |
0.570 |
(1.364,0.325-5.726) |
P = 0.672 |
1.000 |
(5.786,0.703-47.626) |
P = 0.103 |
0.618 |
| 2 studies |
Indian |
34/352 |
(0.695,0.309-1.562) |
P = 0.379 (F) |
1.000 |
(1.421,0.611-3.303) |
P = 0.415 (F) |
1.000 |
(0.817,0.393-1.698) |
P = 0.588 |
1.000 |
| 1 study | Iranian | 10/100 | (1.232,0.231-6.560) | P = 0.807 | 1.000 | (0.940,0.186-4.764) | P = 0.941 | 1.000 | (1.195,0.237-6.025) | P = 0.829 | 1.000 |
Cau/M Cau: Caucasian/Mostly Caucasian; F: fixed model; R: random model; Bon: P for Bonferroni adjustment. The significant contrasts were written in bold.