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(a) Overlay of available crystal structures of HDAC8 represented as ribbons. Structural variation of the L1 and L2 loops is highlighted with a dashed line. (b) Ribbon representation of HDAC8 Tyr306Phe (PDB code 2V5W) in gray bound to a cleavable substrate in green licorice. Insert shows a zoom into the interaction of the binding rail residue Asp101 and the substrate backbone.
