Table 1. Relative Enzymatic Activity of HDAC8 Mutants.

variant	MAL assay [relative]	NMR p53 assay [relative]
WT	100%	100%
Lys33Glu	8% ± 2%	1.8% ± 0.2%
Asp87–89Arg	54% ± 7%	10.1% ± 0.5%
Lys33Glu/Asp87–89Arg	15% ± 3%	11.5% ± 0.5%