Table I.
Summary of interventions and response.
| 7/4 | 7/9 | 7/16 | 8/1 | 8/15 | 8/22 | 8/29 | 9/5 | 9/12 | 9/19 | 9/26 | 10/10 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intervention | Fluid | PE 1.5 PV D Tx | PE 1.5 PV bid Tx | PE + HD Solumedol | DC PE Ecu 900 mg weekly | Ecu 900 mg Tx plts/BC | Ecu 900 mg | Ecu 900 mg | Ecu 1,200 mg | Ecu 1,200 mg | Ecu 1,200 mg | |
| Creatinine (mg/dL) | 0.75 | 4.0 | 2.1 | 1.5 | 1.0 | 1.2 | 1.0 | |||||
| Hb (mg/dL) | 14.4 | 8.8 | 6.0 | 7.5 | 6.9 | 7.9 | 8.0 | 8.8 | 8.8 | 9.0 | 9.4 | |
| Platelets (×109/L) | 267 | 44 | 50 | 50–70 | 70 | 24–50 | 60 | 80 | 84 | 134 | 284 | 214 |
| Retic (%) | 4% | 3% | ||||||||||
| Smear f/HPF | 5–6 | 5–6 | 5–6 | 3 | 2–3 | 2–3 | 2–3 | <1 | <1 | |||
| LDH | 2,330 | 800 | 700 | 700 | 595 | 700 | 600 | 600 | 434 | 239 | 178 |
PE: plasma exchange; PV: plasma volume; D: dialysis; HD: high-dose; DC: discontinued; Ecu: eculizumab; Tx: transfusion; plts: platelets; RBC: red blood cells; f/HPF: fragments/high power field; Retic: reticulocytes; LDH: lactate dehydrogenase.