Table 1.
Clinical features and SNP array results of 18 patients
| histology grade | sample name | bronchial location | biopsy/brush | patient number | SCA detection | smoking history | histology stability |
|---|---|---|---|---|---|---|---|
| SQ | IC-1 | LUL | brush | 1 | Yes | former | - |
| SQ | IC-2 | RLL | brush | 1 | Yes | former | - |
| SQ | IC-3 | RUL | brush | 1 | Yes | former | - |
| SQ | IC-4 | RUL | brush | 2 | Yes | current | - |
| SQ | IC-5 | RUL | biopsy | 3 | Yes | current | - |
| LC | IC-6 | LUDB | biopsy | 4 | Yes | current | - |
|
| |||||||
| CIS | CIS-1 | LUL | biopsy | 5 | Yes | current | persistent |
| CIS | CIS-2 | LUDB | biopsy | 6 | Yes | current | persistent |
| CIS | CIS-3 | LUL | brush | 7 | Yes | current | persistent |
|
| |||||||
| SD | SD-1 | RML | biopsy | 5 | Yes | current | - |
| SD | SD-2 | LLL | brush | 8 | No | former | - |
| SD | SD-3 | RUL | brush | 9 | No | current | regressive |
| SD | SD-4 | RUL | brush | 10 | No | former | - |
|
| |||||||
| MD | MD-1 | LUL | brush | 6 | Yes | current | persistent |
| MD | MD-2 | RUL | brush | 6 | No | current | - |
| MD | MD-3 | LUL(Li) | brush | 7 | Yes | current | persistent |
| MD | MD-4 | RLL | brush | 7 | No | current | - |
| MD | MD-5 | RUL | brush | 11 | No | current | regressive |
| MD | MD-6 | LUL | brush | 12 | No | former | persistent |
| MD | MD-7 | RML | brush | 12 | No | former | regressive |
|
| |||||||
| MiD | MiD-1 | LUL | brush | 12 | No | former | persistent |
| MiD | MiD-2 | LUDB | brush | 13 | No | current | - |
| MiD | MiD-3 | RUL | brush | 14 | No | current | regressive |
| MiD | MiD-4 | RML | brush | 15 | No | former | regressive |
|
| |||||||
| HP | HP-1 | RLL | biopsy | 5 | No | current | - |
| HP | HP-2 | LUL | brush | 16 | No | current | - |
| HP | HP-3 | RUL | brush | 15 | No | former | persistent |
|
| |||||||
| NH | NH-1 | RML | brush | 11 | No | current | - |
| NH | NH-2 | LUDB | brush | 17 | No | former | persistent |
| NH | NH-3 | RML | brush | 18 | No | former | persistent |
The results of Fisher’s exact tests in arrayed patients/lesions with 5–7 histology grade; p = 0.20 in current vs. former smokers with SCA detection compared to no SCA detection, and p = 0.048 in persistence vs. regression of lesions with SCA detection compared to no SCA detection. Disease stability: persistent change; ≤ 1 histology grade, regressive change; ≥ 2 grades, -; no repeated bronchoscopy available. Definition of abbreviations: SQ, squamous cell lung cancer; LC, large cell lung cancer; CIS, carcinoma in situ; SD, severe dysplasia; MD, moderate dysplasia; MiD, mild dysplasia; HP, hyperplasia; NH, normal histology; LUL, left upper lung; LUDB, left upper divisional bronchus; LUL(Li), left upper lung (lingula); LLL, left lower lung; RUL, right upper lung; RML, right middle lung; RLL, right lower lung