Table 1. EFV-modulated miRNAs implicated in tumor progression and localized at cancer associated genomic regions (CAGR) and fragile sites (FRA).

Name	EFV modulation	Preferential sites of expression	Chr	CAGR localization	References
miR-16a	down	CLL, ALL, oral ca	13	D13q14-14.3	56
miR-21	down	CLL	17	FRA17B	56
miR-25	down	HCC	7	FRA7F	33
miR-32	down	prostate ca, HML	9	FRA9E	56, 33
miR-33a	down	CRC, astrocytoma	22	D 22q12.2-q13.33	56
miR-132	down	HCC	17	D 17p13.3	56
miR-181a-2	down	head and neck ca	9	D 9q33-34.1	56
miR-181c	down	osteosarcoma	9		57
miR-23b	up	CLL	9	FRA9D	56
miR-34b	up	breast ca	9		59
miR-125b-2	up	lung ca, myeloid and lymphoid leukemia, breast ca, glyoblastoma	21	D 21q11.1	56
miR-146a	up	CLL	5		58
miR-148a	up	ovarian ca	12		60
miR-193	up	ovarian ca	17	D 17q11.1	56
miR-199	up	bladder ca	9	D 9q33-34.1	56
miR-513a-5p	up	male infertility	X	FRAXA, RAXE	33

CLL, chronic lymphocytic leukemia; HCC, hepatocellular carcinoma; ALL, adult lymphoblastic leukemia; HML, human myeloid leukemia; CRC, colorectal carcinoma