Table 2. EFV-modulated metastamiRs, miRNAs promoting tumor progression, invasiveness and metastasis.

Name	EFV modulation	Modulation in cancer	Biological correlation	Cancer type	References
miR-21	down	up	Correlated with invasion and metastasis	lung, colorectal,	61,62
miR-33a	down	up	Dysregulated expression in bone metastasis from primary prostate	prostate	63
miR-181a	down	up	Related with shortened disease-free survival, highly upregulated in osteosarcoma	osteosarcoma	57
miR-199b	down	up	Expression dysregulated in metastasis	brain	64
miR-34b	up	down	Downregulated in metastasis, reactivated upon drug treatment inhibits tumor growth and lymph node metastasis	colorectal, melanoma, head and neck	65
miR-125b	up	down/up	Downregulated in breast and upregulated in i cancer, association with cancer metastasis	breast, colorectal	37
miR-146a	up	down	Inversely correlated expression with cancer progression and metastasis	prostate, breast	66
miR-148a	up	down	Downregulated in metastasis, acts as metastasis suppressor inhibiting tumor growth and lymph node metastasis	colorectal, melanoma, head and neck	65
miR-193b	up	down	Inversely correlated expression with cancer progression, invasion and metastasis	breast	67
miR-204	up	down	Highly reduced expression in cancer progression; overexpression suppresses invasiveness and acts as metastasis suppressor	head and neck	68