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. 2013 Nov 23;4(12):2419–2429. doi: 10.18632/oncotarget.1572

Figure 4. Persistent MYC expression partially rescues I-BET762-mediated growth effects in LNCaP cells, but has minimal effect in VCaP cells.

Figure 4

A, Western blot analysis of c-Myc expression in LNCaP cells (top) and VCaP cells (bottom) overexpressing GFP or MYC following a three day treatment with 1 µM I-BET762. B, Average gIC50 values from a 6 day growth-death assay for LNCaP or VCaP cells overexpressing GFP or MYC (n=3 for LNCaP; n=2 for VCaP). Asterisk indicates statistical significance as determined by t test (p=0.024). C, Stacked bar graphs representing the average population of cells in various phases of the cell cycle following three day treatment with I-BET762 in LNCaP or VCaP cells overexpressing GFP or MYC (n=2 for LNCaP; n=3 for VCaP).