Table 1. Pathways Most Significantly Down-regulated by I-BET762 in LNCaP Cells.
| Term | Fold Enrichment | p-value |
|---|---|---|
| GO:0006260~DNA replication | 2.966618045 | 1.49E-07 |
| GO:0042254~ribosome biogenesis | 3.356584772 | 9.85E-07 |
| REACT_383:DNA Replication | 3.281781377 | 2.6E-06 |
| GO:0006268~DNA unwinding during replication | 10.00720926 | 4.6E-06 |
| hsa03030:DNA replication | 5.264214047 | 7.62E-06 |
| GO:0006259~DNA metabolic process | 1.878883924 | 1.32E-05 |
| GO:0006270~DNA replication initiation | 8.756308101 | 1.39E-05 |
| GO:0032508~DNA duplex unwinding | 7.783384979 | 3.49E-05 |
| GO:0032392~DNA geometric change | 7.783384979 | 3.49E-05 |
| GO:0022613~ribonucleoprotein complex biogenesis | 2.459637107 | 7.4E-05 |
Top 10 most significantly down-regulated pathways in LNCaP cells treated with 0.5µM I-BET762. Complete functional analyses for LNCaP, VCaP, H660, and PC3 cells are detailed in Supplemental Table S2.