Table 1. Tumorigenic capacity of ALDHhigh and ALDHlow cells in NOD/SCID mice from 4 cervical cancer cell lines.
| Cell line | Sub-population | Cell dose | Tumor-Initiating frequency (95% Interval) | p value | |||||
|---|---|---|---|---|---|---|---|---|---|
| 106 | 105 | 104 | 103 | 102 | 10 | ||||
| SiHa | ALDHhigh | -- | -- | 10/10 | 10/10 | 10/10 | 6/10 | 1:11(1:25—1:5) | <0.001 |
| ALDHlow | -- | -- | 10/10 | 7/10 | 4/10 | 0/10 | 1:586(1:1,162—1:295) | ||
| C33A | ALDHhigh | 10/10 | 9/10 | 4/10 | 2/10 | -- | -- | 1:27,331(1: 57,546—1:12,981) | <0.001 |
| ALDHlow | 6/10 | 1/10 | 0/10 | 0/10 | -- | -- | 1:1,086,487(1:2,331,530—1:506,300) | ||
| CaSki | ALDHhigh | -- | 10/10 | 10/10 | 7/10 | 2/10 | -- | 1:737(1:1,496—1:363) | <0.001 |
| ALDHlow | -- | 10/10 | 6/10 | 0/10 | 0/10 | -- | 1:12,788(1:28,040—1:5,833) | ||
| HT-3 | ALDHhigh | -- | 10/10 | 10/10 | 10/10 | 3/10 | -- | 1:234(1:520—1:105) | <0.001 |
| ALDHlow | -- | 10/10 | 9/10 | 4/10 | 0/10 | -- | 1:3,434(1:6,968—1:1,692) | ||