Table 1. List of AOS response genes highly expressed in cancers which correlate with outcome in breast or lung cancer.
The cancer AOS response signature was analyzed using bioprofiling.de GENE_SRV to identify cancers in which these genes have significant predictive power. Only genes that were found to correlate with survival are shown. Gene name, ENTREZ ID, microarray probeset ID and p value are provided. Kaplan-Meier plots for all the indicated genes are displayed in Figure S1-S3.
| Breast cancer | ENTREZ ID | ||
|---|---|---|---|
| Gene | (probe ID) | P-value | |
| Bad prognosis | BTG3 | 10950 (360504) | 0.00357 |
| CASP3 | 836 (540397) | 0.0000453 | |
| CDC2 | 983 (5360092) | 0.0000105 | |
| ECT2 | 1894 (5420064) | 0.00012 | |
| EGLN1 | 54583 (6130168) | 0.00586 | |
| FOXM1 | 2305 (5390044) | 2.51E-08 | |
| G6PD* | 2539 (5700072) | 0.00748 | |
| GAPDH | 2597 (1940184) | 0.00321 | |
| HMOX1* | 3162 (6180100) | 0.000294 | |
| LONP1 | 9361 (870538) | 0.0031 | |
| NUDT1 | 4521 (6180369) | 0.0016 | |
| PRDX4* | 10549 (940131) | 0.00276 | |
| PSMB5 | 5693 (3610041) | 0.00337 | |
| SELS | 55829 (7100450) | 0.00844 | |
| SERPINE1 | 5054 (6840139) | 0.00167 | |
| SRXN1* | 140809 (3190176) | 0.00336 | |
| TXNRD1* | 7296 (6220603) | 0.00000169 | |
| Good prognosis | PON2 | 5445 (7040022) | 0.00457 |
| SIRT1 | 23411 (6940021) | 0.00918 | |
| Lung cancer | NCBI ID | ||
| NCBI ID | (probe ID) | P-value | |
| Bad prognosis | COL1A1 | 1277 (926) | 0.000675 |
| GAPDH | 2597 (1738) | 0.00185 | |
| GCLC* | 2729 (14771) | 0.00354 | |
| GSS* | 2937 (267) | 0.00934 | |
| NQO1* | 1728 (20812) | 0.0045 | |
| RNF7 | 9616 (12099) | 0.00439 | |
| STK24 | 8428 (10957) | 0.00195 | |
| TXN* | 7295 (10753) | 0.00789 | |
| TXNRD1* | 7296 (8394) | 0.00284 | |
| Good prognosis | NFKB1 | 4790 (3750) | 0.000849 |
*
NRF2 targets