Table 2. List of pathways differentially regulated in MCF-7 cells treated with 2b compound.
| Upregulated | ||
|---|---|---|
| Term | P value | Altered genes |
| hsa05322:Systemic lupus erythematosus | P < 0.0001 | HIST2H2AA3, HIST1H2BC, HIST1H2BD, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2AE, HIST1H2BH, H2AFJ, HIST2H3C, HIST2H3D, HIST2H2AB, HIST2H2BE, HIST2H2AC, HIST1H2BJ, HIST1H4E, HIST1H2AH, HIST1H3D, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H4H |
| hsa00900:Terpenoid backbone biosynthesis | P < 0.0001 | MVD, HMGCS1, FDPS, IDI1 |
| hsa04010:MAPK signaling pathway | P < 0.0001 | FOS, ATF4, JUN, JUND, HSPA6, HSPA1A, HSPA1B, GADD45B, FLNA, DDIT3, ATF2 |
| Downregulated | ||
| Term | P value | Altered genes |
| hsa05012:Parkinson disease | P < 0.0001 | ATP5D, NDUFB5, UQCRC1, COX7A2, NDUFA8, LOC729317, NDUFA9, NDUFB9, COX8A, COX7A2L, COX5A, COX5B, PARK7, VDAC1, LOC402175, SDHD, COX6A1, UBB |
| hsa00190:Oxidative phosphorylation | P < 0.0001 | ATP5D, NDUFB5, UQCRC1, COX7A2, NDUFA8, NDUFA9, COX10, NDUFB9, COX8A, COX7A2L, COX5A, COX5B, ATP6V1A, ATP6V0E2, LOC402175, SDHD, COX6A1 |
| hsa05010:Alzheimer disease | P < 0.0001 | ATP5D, NDUFB5, COX7A2, UQCRC1, NDUFA8, APH1A, NDUFA9, NDUFB9, COX8A, COX7A2L, COX5A, COX5B, ATP2A2, LOC402175, SDHD, PPP3CB, COX6A1, CHP, CALM1 |
| hsa05016:Huntington disease | 6.21E-04 | ATP5D, NDUFB5, UQCRC1, COX7A2, NDUFA8, LOC729317, NDUFA9, NDUFB9, COX8A, COX7A2L, COX5A, COX5B, DCTN2, VDAC1, LOC402175, SDHD, CREB3L2, COX6A1, AP2M1 |
| hsa03010:Ribosome | 0.001104 | MRPL13, RPS3A, RPL34, RPL8, RPL15, RPL27, RPS13, FAU, RPL24, RPL7A, RPS11, RPS3 |
| hsa00970:Aminoacyl-tRNA biosynthesis | 0.001563 | WARS, YARS, DARS, EPRS, IARS2, DARS2, KARS, EARS2 |
| hsa00020:Citrate cycle (TCA cycle) | 0.009441 | SUCLG2, SUCLG1, SDHD, IDH1, PDHB, MDH1 |
| hsa03050:Proteasome | 0.0143 | PSMB5, PSMB7, PSMD14, PSMB6, PSMA6, PSMB2, PSMD2 |
| hsa04142:Lysosome | 0.027671 | LAMP1, LAMP2, AP4E1, AP1G1, PSAP, IGF2R, HEXB, PPT1, SCARB2, GBA, AP3B1 |
| hsa03040:Spliceosome | 0.042939 | LOC100129585, EFTUD2, ZMAT2, SF3B5, RBMX, CTNNBL1, PRPF19, SFRS7, PLRG1, SFRS9, SNRPC, LOC100131735, PUF60 |
| hsa00062:Fatty acid elongation in mitochondria | 0.043188 | ACAA2, PPT1, HADHB |
| hsa04260:Cardiac muscle contraction | 0.048592 | COX7A2, UQCRC1, ATP2A2, COX8A, COX6A1, COX7A2L, COX5A, COX5B |
| hsa00860:Porphyrin and chlorophyll metabolism | 0.050819 | BLVRA, COX10, FTHL3, EPRS, EARS2 |
| hsa00480:Glutathione metabolism | 0.061389 | MGST3, GPX4, RRM1, PGD, LOC642590, IDH1, LOC646347, SMS |
| hsa05120:Epithelial cell signaling in Helicobacter pylori infection | 0.069935 | ATP6V1A, TJP1, ATP6V0E2, MAPK13, RAC1, NFKB1, PTPN11 |
| hsa05014:Amyotrophic lateral sclerosis (ALS) | 0.075133 | DERL1, MAPK13, RAC1, PPP3CB, BCL2L1, CHP |
| hsa04722:Neurotrophin signaling pathway | 0.083546 | MAP2K1, MAPK13, RAC1, YWHAB, YWHAQ, RHOA, NFKB1, CRK, CALM1, PTPN11 |
| hsa00620:Pyruvate metabolism | 0.090327 | ME1, LDHA, GLO1, PDHB, MDH1 |
| hsa04114:Oocyte meiosis | 0.098472 | PPP1CA, MAP2K1, YWHAB, YWHAQ, PPP3CB, PPP2R5E, CHP, PPP1CC, CALM1 |