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. Author manuscript; available in PMC: 2015 Feb 18.
Published in final edited form as: J Am Coll Cardiol. 2013 Nov 27;63(6):549–559. doi: 10.1016/j.jacc.2013.10.062

Figure 2. Accelerated onset of inducible arrhythmias during myocardial ischemia in isolated CAR+/− hearts.

Figure 2

(A) Ischemic zone size after LAD ligation (non-perfused area; as a percentage of the left ventricle) was similar in WT and CAR+/− hearts. (B) Arrhythmia inducibility during LAD ligation. Typical examples of ventricular electrograms show extrastimuli (S1-S4) followed by either no arrhythmia (upper panel), six ventricular extrasystoles (premature ventricular contractions [PVC] - middle panel), or sustained ventricular tachycardia (lower panel). (C) Kaplan Meier plot showing an accelerated onset of first arrhythmic event during myocardial ischemia in CAR+/− hearts (n=9) as compared to WT (n=8). (D,E) CAR+/− hearts display increased inducibility of all types of arrhythmia (D) and of sustained ventricular tachycardia (VT > 3 seconds) (E) during the first 15 minutes of ischemia (*p<0.05).