Fig. 3.
Evaluation of the effects of use of different probenecid inhibition constant (Ki) values on simulated plasma exposure changes of test substrates (AUCR, with and without inhibitor). The dashed lines represent the simulated AUCR, and the solid lines ± shade represent the observed mean ± SD AUCR. a Oseltamivir carboxylate: 150 mg single oral dose with and without probenecid [12]. b Cidofovir: 3.0 mg/kg intravenous infusion over 1 h with and without probenecid [9]. c Cefuroxime: 750 mg intravenous infusion over 20 min with and without probenecid [31]