Table 4.
Distribution of the individual tissue scores on day 21 by endpoint for the chemicals from the RCD (ECETOC and ZEBET) that resulted in a persistent effect in at least one animal (n = 124 animals) a
| Endpoint | Tissue score (proportion of animals) | ||||
|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | |
| CO | 54.0 | 13.7 | 12.1 | 8.1 | 10.5 |
| IR | 82.3 | 8.1 | 8.1 | NA | NA |
| CR | 63.7 | 24.2 | 8.9 | 1.6 | NA |
| CC | 78.2 | 11.3 | 7.3 | 1.6 | 0.0 |
CO corneal opacity, IR iritis, CR conjunctiva redness, CC conjunctiva chemosis, NA not applicable
aIndividual data for day 21 were only available for ECETOC and ZEBET databases. For 2 out of 124 animals, the study stopped before day 21 and the tissue score was not reversed to 0; these two animals were therefore not included in this table