Figure 1.

Schematic figure of relationship between muscle, capillary, and physiological condition. In mdx mice, capillary density is decreased, angiogenesis is impaired with decreased flow induced dilation in arteries. When angiogenesis is enhanced in mdx mice, increased capillary density and improved angiogenesis capacity leads to decreased area of necrosis and fibrosis and increased regenerative capacity in muscle accompanied with increased tissue perfusion and improved muscle weakness.