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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Immunol Rev. 2014 Mar;258(1):80–101. doi: 10.1111/imr.12147

Fig. 2. Mechanisms of peripheral T-cell tolerance implicated in allograft acceptance.

Fig. 2

In addition to thymic negative selection, several mechanisms of peripheral tolerance have been shown to operate in-models of transplantation tolerance. These include T-cell-intrinsic and T cell-extrinsic mechanisms.