Table 3.

Correlation between Markers of Bone Health and Markers of Inflammation and Immune Activation

	Hip BMD	Spine BMD	Bone Resorption CTX	Bone Formation
				Osteocalcin	PINP	25-OH vitamin D
Bone Turnover
CTX	−0.16	−0.16	--	--	--	--
Osteocalcin	−0.18a	−0.13	0.56c	--	--	--
PINP	−0.002	−0.05	0.60c	0.59c	--	--
25(OH) vitamin D	−0.27c	−0.17a	−0.15	0.05	−0.26b	--
Inflammatory Markers
IL-6	0.13	0.08	−0.06	−0.04	−0.15	−0.11
CRP	0.11	0.09	−0.11	−0.08	−0.06	0.02
d-dimer	0.05	0.13	0.01	−0.04	0.072	−0.10
RANKL	0.01	0.14	0.10	0.11	0.14	−0.10
OPG	0.02	0.10	−0.10	−0.07	−0.09	0.15
RANKL:OPG	0.003	−0.13				−0.11
sTNFR-I	−0.07	−0.04	−0.03	0.09	−0.07	0.17
sTNFR-II	−0.04	−0.08	0.10	0.07	0.001	0.10
sICAM-1	−0.03	−0.04	−0.20a	−0.03	−0.03	0.16
sVCAM-1	−0.22b	−0.23b	0.23b	0.33c	0.20a	0.18a
Cellular T-cell Activation Markers
CD4+ CD38/HLA-DR	0.005	−0.01	0.009	0.05	0.12	−0.04
CD4+CD38+HLA-DR+ PD1+	0.03	−0.10	0.05	0.02	0.10	−0.09
CD8+CD38+HLA-DR+	−0.02	−0.04	0.03	0.04	0.08	0.002
CD8+CD38+HLA-DR+ PD1+	−0.04	−0.12	0.01	0.02	0.02	−0.005
Soluble Monocyte Activation Markers
sCD14	−0.10	−0.05	−0.002	−0.020	−0.02	0.13
sCD163	0.04	0.05	−0.16	−0.04	−0.14	0.24b
Cellular Monocyte Activation Markers
CD14dim CD16+	0.10	0.05	−0.11	−0.08	−0.02	−0.03
CD14+ CD16/TF	0.06	0.08	−0.03	−0.04	0.09	0.18a
CD14dim CD16/TF	−0.02	0.05	−0.05	−0.03	0.05	0.13

All values represent Spearman correlation coefficients;

^ap <0.05;

^bp <0.01;

^cp <0.001.

BMD, bone mineral density; CTX, c-terminal collagen crosslinks; PINP, intact N-terminal propeptide of type 1 procollagen; IL-6, interleukin-6; hsCRP, highly sensitive C-reactive protein; RANKL, receptor activator of NF-kB ligand; OPG, osteoprotegerin; sTNFR, soluble tumor necrosis factor-α receptor; sICAM, soluble intracellular adhesion molecule; sVCAM, soluble vascular cell adhesion molecule-1 (sVCAM-1).