Figure 2.

Rapid section of virus‐specific T cells. Peptide‐HLA multimers (A) and cytokine‐secretion capture (B) have both been used clinically to select virus‐specific T cells for adoptive transfer. Multimer selection isolates T cells based on the ability of their TCR to bind to a complex of synthetic peptide‐loaded recombinant HLA molecules, while the cytokine capture approach selects T cells (both CD4⁺ and CD8⁺) based on their ability to secrete effector cytokines in response to viral antigen stimulation.