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Key residues around the ATP binding sites of various kinases. Residue type and number according to AKT2: 1: Ala179 2: Met229, Glu230, Tyr231, Ala232 3: Met282 4: Glu236 5:Lys181 6:Thr292. Upper panel, >85% inhibition; lower panel, ≤10% inhibition.