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. Author manuscript; available in PMC: 2014 May 9.

Published in final edited form as: J Med Chem. 2013 Apr 23;56(9):3456–3466. doi: 10.1021/jm4002692

IC₅₀ values for inhibited kinases. a) The analogs were tested at nine different concentrations using serial dilutions: 3 (EF24), 4 (EF31), 5 (UBS109), 6, 7. Assays for RAF1 and MEK used the kinase cascade method diagramed in Figure 4 and discussed in the Materials and Methods section.

graphic file with name nihms-472308-f0005.jpg — IC₅₀ values for inhibited kinases. a) The analogs were tested at nine different concentrations using serial dilutions: 3 (EF24), 4 (EF31), 5 (UBS109), 6, 7. Assays for RAF1 and MEK used the kinase cascade method diagramed in Figure 4 and discussed in the Materials and Methods section.