TABLE 3.
Kinetic parameters of apoB-48 in TRLs and apoB-100 in VLDLs, IDLs, and LDLs in insulin-sensitive and insulin-resistant subjects
| Kinetic parameters | Insulin-Sensitive Subjects (n = 10) | Insulin-Resistant Subjects (n = 14) | %Δa | P |
| TRL apoB-48 | ||||
| PS (mg) | 24.8 (14.3–33.7) | 50.2 (28.5–81.9) | +102 | <0.0001 |
| FCR (pools/day) | 6.7 (1.5–13.9) | 4.8 (1.7–11.4) | −28.4 | 0.13 |
| PR (mg/kg/day) | 1.5 (0.5–2.7) | 2.8 (0.8–5.8) | +86.7 | 0.01 |
| VLDL apoB-100 | ||||
| PS (mg) | 218 (100–347) | 460 (308–681) | +111 | <0.0001 |
| FCR (pools/day) | 8.2 (5.1–11.9) | 5.4 (3.8–8.4) | −34.1 | 0.0006 |
| PR (mg/kg/day) | 18.1 (14.7–27.4) | 25.3 (19.8–34.4) | +39.8 | 0.0006 |
| IDL apoB-100 | ||||
| PS (mg) | 46.4 (22.0–87.4) | 60.4 (24.9–119) | +30.2 | 0.21 |
| FCR (pools/day) | 24.4 (10.9–48.7) | 17.9 (5.7–32.4) | −26.6 | 0.16 |
| PR (mg/kg/day) | 10.1 (5.8–15.0) | 11.0 (3.5–21.1) | −8.9 | 0.67 |
| LDL apoB-100 | ||||
| PS (mg) | 2,136 (1,080–3,730) | 3,180 (1,175–6,592) | +48.9 | 0.08 |
| FCR (pools/day) | 0.54 (0.34–1.00) | 0.39 (0.10–0.79) | −27.8 | 0.06 |
| PR (mg/kg/day) | 10.9 (8.5–13.9) | 11.5 (6.2–20.8) | +5.5 | 0.68 |
Data are presented as mean (range).
a
%Δ represents the percent difference between the two groups.