TABLE 5.
Summary of the correlations between the mRNA levels of key intestinal genes in the insulin-sensitive subjects (n = 10)
| Genes | SREBP-1c | SREBP-2 | HNF-4α | HMG-CoAR | ACAT-2 | NPC1L1 | ACS-1 | FABP-2 | FATP-4 | MTP | ApoB |
| SREBP-2 | 0.32 | — | |||||||||
| HNF-4α | 0.22 | 0.34 | — | ||||||||
| HMG-CoAR | 0.10 | 0.90b | 0.16 | — | |||||||
| ACAT-2 | 0.10 | 0.91b | 0.25 | 0.93c | — | ||||||
| NPC1L1 | −0.03 | 0.32 | 0.66a | 0.07 | 0.26 | — | |||||
| ACS-1 | 0.47 | 0.89b | 0.26 | 0.89b | 0.81a | 0.05 | — | ||||
| FABP-2 | −0.04 | 0.18 | 0.30 | 0.20 | 0.05 | −0.08 | 0.34 | — | |||
| FATP-4 | −0.04 | 0.19 | 0.66a | 0.02 | −0.02 | 0.47 | 0.15 | 0.76a | — | ||
| MTP | 0.11 | 0.49 | 0.53 | 0.33 | 0.33 | 0.28 | 0.47 | 0.79a | 0.74a | — | |
| ApoB | 0.16 | 0.28 | 0.25 | 0.08 | 0.08 | 0.34 | 0.31 | 0.68a | 0.75a | 0.66a | — |
| LDLR | 0.39 | 0.63a | 0.10 | 0.59 | 0.71a | 0.14 | 0.60a | −0.34 | −0.27 | −0.03 | −0.11 |
The correlation analyses were performed using Spearman's rank order correlation test. HMG-CoAR, HMG-CoA reductase; NPC1L1, Niemann-Pick C1-like 1.
P < 0.05.
P < 0.001.
P < 0.0001.