Table 1. Comparison of human phenotype with different mice genotype for NMHC IIB.

Organ system	Human	HMHC IIB-B-/B- mice	NMHC IIB BR709C/BR709C mice
Perinatal	Intrauterine growth restriction (IUGR), oligohydramnios, unilateral multycystic dysplastic kidney	Intrauterine growth restriction. Perinatal lethal by E14.5	Mostly perinatal lethal by E14.5, IUGR
Central nervous system	Microcephaly, small cerebellar cortex, small cerebellum and hydrocephalus	Dome shaped head, hydrocephalus, disorders of neuronal migration, small cerebellum	Microcephaly, small and underdeveloped cerebellum, abnormalities in the cerebellar foliation pattern
Heart (Gross)	No phenotype	Abnormal rounded shape of the heart, defect in the membranous portion of the ventricular system, narrowing of RVOT by hypertrophied muscle, malposition of the aorta to the right, overriding aorta	Double outlet right ventricle and ventricular septal defect
Heart (Microscopic)	No phenotype	Marked myocyte hypertrophy (increase in transverse myocyte diameter) from E12.5	Cardiac myocyte hypertrophy
Diaphragm	Silent congenital diaphragmatic hernia	Failure of the ventral wall closure including anterior congenital diaphragmatic hernia
Other	Bilateral undescended testicles, congenital hip dysplasia	Retinal dysplasia with rosette formation