TABLE 2.
Effect of CaSR-AAA and DAA supplementation on calcium-related metabolites and calcium absorption in young women1
| Control |
CaSR-AAA supplementation |
DAA supplementation |
||||
| Day 1 | Day 5 | Day 1 | Day 5 | Day 1 | Day 5 | |
| Participants, n | 14 | 14 | 14 | 14 | 14 | 14 |
| Serum metabolites | ||||||
| 1,25-Dihydroxyvitamin D, pmol/L | 151 ± 13 | 163 ± 8 | 162 ± 12 | 155 ± 12 | 172 ± 14 | 166 ± 13 |
| Intact PTH, nmol/L | 36 ± 6 | 31 ± 6 | 31 ± 7 | 30 ± 6 | 32 ± 9 | 31 ± 7 |
| GFR, mL/(min · 1.73 m2) | 91 ± 5 | 97 ± 6 | 90 ± 5 | 91 ± 6 | 93 ± 5 | 94 ± 6 |
| 24-h urine metabolites, mmol | ||||||
| Sodium | 90.8 ± 12.6 | 74.9 ± 6.7 | 80.9 ± 10.7 | 86.4 ± 8.2 | 80.2 ± 7.5 | 90.1 ± 9.7 |
| Calcium | 4.6 ± 1.1 | 2.9 ± 0.3a | 3.9 ± 0.6 | 3.3 ± 0.3 | 4.2 ± 0.6 | 3.8 ± 0.5b |
| Phosphorus | 18.4 ± 1.8 | 11.4 ± 1.2a | 15.6 ± 1.7 | 12.0 ± 1.2a | 18.2 ± 1.4 | 12.7 ± 1.3a |
| Calcium absorption, % | ||||||
| Intestinal calcium absorption | 22.3 ± 1.4 | 22.9 ± 2.0 | 25.2 ± 1.4c | |||
1
Values are means ± SEMs. aDifferent from corresponding baseline, P < 0.05; bdifferent from control, day 5, P < 0.05; cdifferent from control, day 5, 0.05 < P < 0.10. CaSR-AAA, calcium-sensing receptor-activating amino acid; DAA, dibasic amino acid; GFR, glomerular filtration rate; PTH, parathyroid hormone.