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Classes of candidate circulating biomarkers in malignant gliomas
| Circulating tumor marker class | |||
|---|---|---|---|
| Nucleic acids | Tumor cells | Proteins | |
| Specificity | High | High | Variable; often not tumor specific |
| Sensitivity | Variable | No preliminary data published | High |
| Examples | Circulating tumor DNA | Proof of glioma CTC existence: | GFAP |
| Mutations / Deletions | Cases of gliomas with distant metastases | VEGF | |
| Rearrangements | Organ transplant cases | EGFR | |
| Methylation | b-FGF | ||
| RNA | YKL-40 | ||
| miRNA | MMP-9 | ||
| RNA from microvesicles | |||
