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. 2014 Feb 15;8:18. doi: 10.1186/1752-0509-8-18

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Copyright © 2014 Hellweger et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Model-data comparison and heterogeneity source and pathway analysis. (A) Damage (m_D/m) vs. age (n_B). Data from [33]. (B) Tsl1 expression (e_Tsl1) distribution of cells. (C) Age (n_B) vs. Tsl1 expression (e_Tsl1). (D) Heat shock survival of various Tsl1-sorted fractions. Data from [15]. “a.u.” is arbitrary units. (E) Distribution of heat shock tolerance for base case and various diagnostic simulations (e.g. “dam” has equal damage partitioning, s_d = 0.5). (F) Heterogeneity network. Line weight indicates contribution of node or link to overall heterogeneity in heat shock tolerance (based on variance of normalized H_t, e.g., panel E). For details of experiments used to generate the data the reader is referred to the source publications.