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Types of homology of multidomain proteins: orthologs and paralogs. (a) Orthologous multidomain proteins with identical DA—human and mouse tissue plasminogen activator; (b) Paralogous multidomain proteins with identical DA—human factor 9 and human factor 10; (c) Orthologous multidomain proteins with different DA—human and mouse neurotrypsin; and (d) Paralogous multidomain proteins with different DA—human tPA and human urokinase.
