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. 2011 Aug 2;2(3):516–561. doi: 10.3390/genes2030516

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Analysis of the positional distribution of DA differences of paralogous human Swiss-Prot sequences differing in single domains. The numbers on the abscissa indicate the number of top-scoring matches included in the analyses (TSS = 1, …. TSS = 7) used to define paralogous clusters. N-terminal differences (blue recrangles), C-terminal differences (red rectangles), internal differences (green rectangles), tandem duplications (black rectangles). (a) Positional distribution of DA differences for type 1 transitions; (b) Positional distribution of DA differences for type 2 transitions (note that, in the case of the closest paralogs (TSS = 1), the proportion of terminal and internal DA differences are comparable); and (c) Positional distribution of DA differences for type 3 transitions. Note that in the case of closest paralogs (TSS = 1 and TSS = 2) the proportion of internal DA difference exceeds those of N-terminal or C-terminal changes.