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. 2011 Aug 2;2(3):516–561. doi: 10.3390/genes2030516

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Analysis of the DA of paralogous clusters of human Swiss-Prot proteins defined through comparison with RefSeq proteomes of various species. The ordinate shows the proportion of pair-wise comparisons within clusters where the pairs differ in DA. On the abscissa the species are listed in the order of decreasing evolutionary distance from Homo sapiens, thus the abscissa has a time-dimension but their distance is not drawn to scale. Note that there is a significant drop in the proportion of pairs that differ in DA at the boundary of the invertebrate/vertebrate transition. Abbreviations on the abscissa: Ta - Trichoplax adhaerens, Nv - Nematostella vectensis, Hm - Hydra magnipapillata, Ce -Caenorhabditis elegans, Cb -Caenorhabditis briggsae, Dm -Drosophila melanogaster, Dp -Drosophila pseudoobscura, Ds - Drosophila simulans, Sp - Strongylocentrotus purpuratus, Bf - Branchiostoma floridae, Ci - Ciona intestinalis, Dr - Danio rerio, Xt - Xenopus tropicalis, Gg - Gallus gallus, Mm - Mus musculus.