Table S6.

Positional distribution of DA differences of paralogous human Swiss-Prot proteins defined through intraspecies comparisons.

Type of DA Difference**
Dataset*	Transition Type	Nterm	Cterm	Internal	Duplication	NA	Identical
TSS=1	1	38	39	9	9	5	0
	2	37	24	19	17	2	0
	3	21	10	39	30	1	0
TSS=2	1	42	33	10	10	5	0
	2	39	34	13	11	2	0
	3	25	16	33	26	1	0
TSS=3	1	38	34	11	9	8	0
	2	41	34	14	9	3	0
	3	30	25	26	18	1	0
TSS=4	1	49	36	6	6	3	0
	2	42	33	14	8	3	0
	3	35	30	20	14	1	0
TSS=5	1	50	37	5	5	3	0
	2	44	36	11	6	3	0
	3	36	33	18	13	1	0
TSS=6	1	51	42	3	3	2	0
	2	47	43	5	3	2	0
	3	47	45	5	3	1	0
TSS=7	1	50	44	3	3	1	0
	2	48	43	5	3	2	0
	3	48	45	4	3	1	0

^*Datasets containing the top-scoring one, two… seven sequences (TSS=1, TSS=2….TSS=7 datasets) were created as described in the text.

^**The numbers in the different categories represent the percen t of total assignments