Figure 5.

Changes in chromatin fiber density may distinguish pluripotent and differentiated cell types. Schematic view (interpreted from the experimental data in reference [29]) of nuclei from pluripotent cells (left) and differentiated cells (right) using electron spectroscopic imaging to visualize the chromatin organization. Undifferentiated cells have a less compact, more euchromatin (open chromatin structure) as compared with the heterochromatin (closed chromatin structure) present in differentiated cells.