Table 1.
Risk of SPC a by gender, age, year of first cancer diagnosis and follow-up, France 1989–2004 (N = 289,967)
| O | E | PYR | SIR | (95% CI) | EAR b | (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
|
All patients |
21,226 |
15,555.59 |
1,440,960 |
1.36 |
(1.35-1.38) |
39.4 |
(37.4-41.3) |
|
|
Gender |
Male |
14,555 |
10,514.87 |
689,115 |
1.38 |
(1.36-1.41) |
58.6 |
(55.2-62.1) |
| |
Female |
6,671 |
5,040.73 |
751,845 |
1.32 |
(1.29-1.36) |
21.7 |
(19.6-23.8) |
|
Age at first cancer diagnosis |
≤ 44 y |
909 |
424.88 |
210,515 |
2.14 |
(2.00-2.28) |
23.0 |
(20.2-25.9) |
| 45 y-54 y |
2,592 |
1,270.67 |
236,678 |
2.04 |
(1.96-2.12) |
55.8 |
(51.7-60.1) |
|
| 55 y-64 y |
5,284 |
3,500.56 |
334,536 |
1.51 |
(1.47-1.55) |
53.3 |
(49.1-57.6) |
|
| 65 y-74 y |
7,772 |
6,235.67 |
406,356 |
1.25 |
(1.22-1.27) |
37.8 |
(33.6-42.1) |
|
| ≥ 75 |
4,669 |
4,123.81 |
252,874 |
1.13 |
(1.10-1.17) |
21.6 |
(16.3-26.9) |
|
|
Year of first cancer diagnosis |
1989-1994 |
7,512 |
5,406.49 |
517,048 |
1.39 |
(1.36-1.42) |
40.7 |
(37.5-44.0) |
| 1995-1999 |
7,679 |
5,634.00 |
520,856 |
1.36 |
(1.33-1.39) |
39.3 |
(36.0-42.6) |
|
| 2000-2004 |
6,035 |
4,515.10 |
403,057 |
1.34 |
(1.30-1.37) |
37.7 |
(34.0-41.5) |
|
|
Follow-up |
≥ 2 m- < 1 y |
3,170 |
2,280.81 |
213,502 |
1.39 |
(1.34-1.44) |
41.6 |
(36.5-46.9) |
| |
≥ 1 y- < 2 y |
3,034 |
2,229.98 |
210,970 |
1.36 |
(1.31-1.41) |
38.1 |
(33.0-43.3) |
| |
≥ 2 y- < 4 y |
4,983 |
3,665.14 |
343,730 |
1.36 |
(1.32-1.40) |
38.3 |
(34.3-42.4) |
| |
≥ 4 y- < 6 y |
3,504 |
2,614.81 |
241,999 |
1.34 |
(1.30-1.39) |
36.7 |
(32.0-41.6) |
| |
≥ 6 y- < 8 y |
2,522 |
1,815.96 |
166,357 |
1.39 |
(1.34-1.44) |
42.4 |
(36.6-48.5) |
| |
≥ 8 y- < 10 y |
1,664 |
1,239.15 |
112,267 |
1.34 |
(1.28-1.41) |
37.8 |
(30.8-45.1) |
| ≥ 10 y | 2,349 | 1,709.75 | 152,135 | 1.37 | (1.32-1.43) | 42.0 | (35.8-48.4) | |
SPC, second primary cancer; O, Observed; E, Expected; PYR, person-years at risk; SIR, standardized incidence ratio; EAR, excess absolute risk; CI, confidence interval; m, months; y, years.
aExcluding SPC occurring in the same subsite as the first primary cancer.
bNumber of excess cancers per 10,000 person-years at risk.