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. 2014 Feb 15;11:4. doi: 10.1186/2045-8118-11-4

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Copyright © 2014 Kim et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CSF outflow correlated with drug concentration at (A) 25 cmH₂O and (B) 45 cmH₂O ICP. In order to address whether a correlation existed between CSF outflow and an overall drug effect, data points from all agents tested at no drug treatment (NT), the delivery of the first set of agents (Drug Conc.#1; 50 μM NA, 10 μM L-NMMA, 0.1 μM U46619) and the delivery of the second set of agents (Drug Conc.#2; 500 μM NA, 100 μM L-NMMA, 1 μM U46619) were plotted against CSF outflow, which was calculated from linear regression analysis derived from the raw data using steady-state pressures of (A) 25 cmH₂O and (B) by extrapolation at 45 cmH₂O. The straight line linking the averages within each treatment group was calculated with the Pearson correlation test.