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. 2014 Feb 15;11:4. doi: 10.1186/2045-8118-11-4

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Copyright © 2014 Kim et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Increasing drug dose resulted in a significant increase in CSF outflow at 45 cmH₂O ICP. In order to stratify the correlation of the specific drug effects at a steady-state pressure of 45 cmH₂O, we plotted drug concentrations against CSF outflow using extrapolated data. (A) saline delivery, (B) noradrenaline (NA) at 50 μM and 500 μM (n = 5), (C) L-NMMA at 10 μM and 100 μM (n = 4), (D) U46619 at 0.1 μM and 1.0 μM (n = 5) and (E) U46619 at 1 mM, 25 cmH2O (n = 3). Asterisk denotes significance relative to no drug treatment (NT) (ANOVA/Dunnett’s test).