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. Author manuscript; available in PMC: 2014 Feb 18.
Published in final edited form as: J Am Chem Soc. 2013 Oct 25;135(44):16397–16409. doi: 10.1021/ja405239v

Figure 6.

Figure 6

Representative images of APP-PS1 transgenic and wild type control mice at different time points before and after i.v. injection with 2.0 mg/kg of CRANAD-58 (Images of all mice showed in SI Fig.7b). (a) 4-month old APP-PS1 mouse. (b) 4-month old control mouse. (c) Quantitative analysis of fluorescence signals from transgenic APP/PS1 mice and control mice (n=3–4) at pre-injection, and 5, 10, 30, 60, 120 and 240 min after i.v. injection. The signals were significantly higher in 4-month old APP/PS1 mice than that in the age matched control mice. (d) Representative high-resolution image of an APP/PS1 mouse injected with CRANAD-58.