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. Author manuscript; available in PMC: 2014 Feb 18.
Published in final edited form as: J Am Chem Soc. 2013 Oct 25;135(44):16397–16409. doi: 10.1021/ja405239v

Figure 7.

Figure 7

(a) Clioquinol, a bidentate ligand for copper, coordinates with copper to form intramolecular complex (top); mono-dentate compound does not form intramolecular complex with copper. (b) The proposed interaction model between Aβ (HHQKLVFF segment shown) and the designed imidazole-containing curcumin analogue. (c) Fluorescence spectra of CRANAD-17 alone (black), with Aβ40 (red), and with [H13R]Aβ40 (blue). (d) 1H NMR spectra of KLVFF (top) and of KLVFF with CRNAD-17 (bottom). * Indicated that the peaks originated from ligand CRANAD-17.