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. 2013 Nov 26;4:2041731413515670. doi: 10.1177/2041731413515670

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© The Author(s) 2013

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 7. — Real-time RT-PCR analysis. Relative mRNA expression levels for COL1A1, ALPL, BMP2, VEGFA, TNFRSF11B and BGLAP are shown in osteoblasts cultured on scaffolds with 10 nM and 10 µM SIM compared to scaffolds without SIM and normalized to reference gene GAPDH at 7, 14 and 21 days. Values represent the mean ± SD. Statistical analysis: (a) p ≤ 0.05 versus alginate-coated scaffold without SIM and (b) p ≤ 0.05 versus alginate-coated scaffold with SIM 10 µM.

SIM: simvastatin; RT-PCR: reverse transcriptase–polymerase chain reaction; mRNA: messenger RNA; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; COL1A1: collagen type I alpha 1; ALPL: alkaline phosphatase; BMP2: bone morphogenetic protein 2; VEGFA: vascular endothelial growth factor A; TNFRSF11B: osteoprotegerin; BGLAP: osteocalcin; SD: standard deviation.