Table 2. IC50 Values of Maraviroc Derivatives in Neutralization Assays against Indicated Strains.
IC50 (nM) of Maraviroc derivativesa |
|||
---|---|---|---|
HIV-1 strain | 1 | 7 | 12 |
92RW (clade A) | 1.3 ± 0.5b | 8.1a | 3.0a |
JR-FL (clade B) | 1.6 ± 0.3c | 7.7 ± 0.5b | 5.6 ± 2.0d |
YU-2 (clade B) | 0.43 ± 0.1b | 2.8a | 2.5a |
MGC26 (clade C) | 0.37 ± 0.01b | 2.7a | 0.8a |
Average (N = 2).
Mean ± SE (N = 3).
Mean ± SE (N = 12),
Mean ± SE (N = 5).