Table 1. Characteristics of 1,321 non-small-cell lung cancer patients.
| Patient Characteristics | α1ATD Carriers (179) No. (%) |
α1ATD Non-carriers (1142) No. (%) |
P value |
|---|---|---|---|
| Age | 0.88 | ||
| Mean (SD) | 65.7 (10.2) | 65.4 (11.1) | |
| Median (range) | 67.0(37.0-86.0) | 67.0 (18.0-92.0) | |
| Gender | 0.74 | ||
| Female | 78 (43.6) | 513 (44.9) | |
| Male | 101 (56.4) | 629 (55.1) | |
| Race | 0.13 | ||
| Caucasian | 162 (90.5) | 1067 (93.6) | |
| Non-Caucasian | 17 (9.5) | 73 (6.4) | |
| Missing | 0 | 2 | |
| Stage | 0.79 | ||
| I | 75 (41.9) | 440 (38.5) | |
| II | 18 (10.1) | 109 (9.5) | |
| III | 47 (26.3) | 314 (27.5) | |
| IV | 39 (21.8) | 279 (24.4) | |
| Smoking status | 0.69 | ||
| Never | 27 (15.2) | 169 (15.2) | |
| Former | 96 (53.9) | 633 (56.9) | |
| Current | 55 (30.9) | 310 (27.9) | |
| Missing | 1 | 30 | |
| Pack years | 0.77 | ||
| Never smokers | 27 (15.1) | 168 (14.7) | |
| ≤40 | 65 (36.3) | 405 (35.5) | |
| >40 and <60 | 34 (19.0) | 255 (22.4) | |
| ≥60 | 53 (29.6) | 312 (27.4) | |
| Missing | 0 | 2 | |
| Histologic cell type | 0.36 | ||
| Adenocarcinoma | 99 (55.3) | 682 (59.7) | |
| Squamous | 57 (31.8) | 305 (26.7) | |
| Others† | 23 (12.8) | 155 (13.6) | |
| Initial treatment | 0.33 | ||
| Surgery | 93 (54.7) | 650 (60.0) | |
| Radiation or chemotherapy, or both |
60 (35.3) | 322 (30.7) | |
| Other or none | 17 (10.0) | 111 (10.3) | |
| Missing | 9 | 59 | |
| Serum α1AT concentration, mg/dL | <0.0001 | ||
| Mean (SD) | 138.6 (42.09) | 199.3 (70.99) | |
| Median (range) | 127.0 (56.0-249.0) | 178.0 (88.0-496.0) | |
| Missing or outliers | 10 | 8 |
Abbreviations: α1ATD, alpha 1-antitrypsin deficiency; α1AT, alpha 1-antitrypsin; α1AT, alpha-1 antitrypsin; SD, standard deviation.
†
Includes large cell, not specified non-small-cell lung cancer, adenosquamous carcinoma, sarcomatoid, and other mixed cell types.