Skin |
In 25–30% of patients19
|
Localized erythematous plaque near affected mucosal surfaces, generalized bullous eruption particularly on the head and upper body, or vegetating lesions occasionally 102, 103
|
Scarring, cicatricial alopecia on the scalp 104, 105
|
|
Oral cavity |
In over 85% of patients |
Desquamative gingivitis, erosions, ulceration (Fig. 1) |
Pseudomembrane |
Vesicles rarely seen (Fig. 2), bleeding |
Pain and inability to eat certain types of food |
Self-limiting mostly |
Mild scarring or atrophy, intraoral adhesion, loss of teeth rarely |
|
Eye |
The second most common site (in 65% of patients) 106
|
Nonspecific conjunctivitis |
Erosions, corneal damage |
Photophobia and photosensitivity, dryness |
Progressive process leading to scarring |
Symblepharon (Fig. 4), ankyloblepharon, trichiasis, entropion |
Blindness in close to 15% of patients |
|
Nose |
In 20–40% of patients |
Discharge, erosion, excessive crust |
Scarring |
Breathing difficulty |
|
Larynx |
In 5–15% of patients |
Sore throat, hoarseness |
Scarring, stenosis of airway |
Breathing difficulty |
|
Esophagus |
In 5–15% of patients |
Dysphagia, odynophagia, esophageal reflux |
Stricture formation |
Disability in eating |
Death |
|
Anogenital area |
In 20% of patients |
Erosion and ulceration |
Bleeding |
Pain |
Dysuria |
Sexual dysfunction |