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. Author manuscript; available in PMC: 2014 Nov 11.
Published in final edited form as: Cancer Cell. 2013 Nov 11;24(5):631–644. doi: 10.1016/j.ccr.2013.10.009

Figure 4. CXCR2 ligands are elevated in colitis-associated tumor and matched inflamed mucosa.

Figure 4

(A) CXCL1, CXCL2, and CXCL5 protein levels were measured in tumors (T) and adjacent mucosa (N) taken from mice treated with AOM/DSS as well as in normal colon tissues taken from mice fed with water only as described in Figure 1A. (B) CXCL1, CXCL2, and CXCL5 induced chemotaxis in WT MDSCs but not in Cxcr2−/− MDSCs in vitro. WT and Cxcr2−/− MDSCs were isolated from blood of AOM/DSS-treated WT and Cxcr2−/− mice, respectively. Values are reported as the mean ± SEM (6 mice for each group). *p<0.05; **p<0.01. See also Figure S3.