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. 2014 Feb 18;9(2):e86489. doi: 10.1371/journal.pone.0086489

Figure 3. Mild hyperthermia treatment enhances MSV accumulation in a time-dependent manner.

Figure 3

A) Representative IVM tissue images of SUM159 tumor show higher accumulation in tumors receiving MHT when analyzed 5 h after treatment; B) quantitative analyses time-dependent increase in accumulation with ∼6-fold increase at 5 h and a reduction in enhancement at 24 h post-treatment (3-fold); C) Histological IVM image illustrating increased MSVs in MCF-7 (less vascularized cell line); D) Quantitative analyses showed similar time-dependent increases in MCF-7 which abated at 24 h. At each time-point, MSVs were injected and allowed 1 h to circulate before analyses. Error bar represents replicates of n = 6, with statistical significance denoted by *** p<0.0001; ** p<0.005; ** p<0.01 for SUM159 and ** p<0.0045 and * p<0.02 for MCF-7 line.