Table 2.

Potential target proteins/molecules modulated by tasquinimod

Potential target proteins/molecules in CPRC	Level in CPRC	Change in levels in response to tasquinimod
Thrombospondin-1	Low	Increased
Vascular endothelial growth factor	High	Decreased
Fibroblast growth factor	High	Decreased
Hypoxia induced factor-1α protein	High	Decreased
Androgen receptor protein	High	Decreased
Stromal derived factor-1	High	Decreased
Lysyl oxidase	High	Decreased

Abbreviation: CRPC, castrate-resistant prostate cancer.