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| CDKs | IC50 (nm) | non-CDKs | IC50 (nm) |
|---|---|---|---|
| K9/T1 | 1 | Fms | 1 |
| K1/B1 | 2 | GSK-3β | 3 |
| K2/E | 3 | TAK1 | 5 |
| K4/D1 | 4 | JNK1a1/2 | 17/40 |
| K3/E | 5 | C-src | 25 |
| K5/p35 | 5 | AMPK | 41 |
| K7/H | 44 | Jak2 | 50 |
| K6/D3 | 55 | MEK1 | 54 |
Note: RGB-286638 multi-targeted kinase activity as measured by in vitro cell-free kinase assays.
Table 1 contains the IC50 kinase inhibition Ki (nM) of individual CDKs and selected tyrosine and serine/threonine kinases (determined in biochemical kinase assays).
