Figure 5. Effects of SWS levels on TOCP-induced behavioral deficits.

A. Wild type flies treated with 8 mg/ml or 16 mg/ml TOCP show a significantly reduced performance in the fast phototaxis assay. B. A similar deficit is detectable in 14 d old control flies (expressing lacZ pan-neuronally; elav>lacZ) treated with 8 mg/ml TOCP. Expressing additional SWS pan-neuronally (elav>SWS) does not protect 14 d old flies from behavioral deficits caused by TOCP however heterozygosity for sws¹ (sws/WT) protects flies from the TOCP induced behavioral deficits (treated WT to sws/WT, *p<0.05). C. Comparing untreated flies in the phototaxis assay shows that overexpression of SWS alone results in less successful transitions already in 7 d old flies. This effect is even more severe when untreated 14 d old flies are tested. The analysis in A was done using one-way ANOVA with a Dunett's post test and the analyses in B, C with a Student's t-test, comparing treated and untreated flies of each genotype (in B) and control and SWS overexpressing flies of a given age (in C). n = is number of groups tested with 10–20 flies each. All flies were females. SEMs are indicated in all graphs. *p<0.05, ***p<0.001. (The was no significant difference in the variance in any of the comparisons).