Table 2.

ARFI-Monitored Hemostatic Challenge Bleeding Rates & Times to Hemostasis by Dog Phenotype.

Hemostasis Phenotype Dog Genotype	n	Mean Bleeding Rate (mm2/min)	Mean Time to Hemostasis (min)*
Normal Hemostasis
1. Normal	6	0.62 ± 0.33#	17.52 ± 6.05§
Abnormal Secondary Hemostasis
2. Naïve Hemophilia A	8	0.86 ± 0.34#	>30§
3. Hemophilia A+FVIII to 11.3 ± 1.8% of normal	8	0.61 ± 0.30#	28.40 ± 12.39§
4. Hemophilia A expressing FVIIa at 1.3 – 2 μg/ml [37]	3†	0.62 ± 0.29#	26.09 ± 5.58§
Abnormal Primary Hemostasis
5. Naïve VWD	6	1.72 ± 0.43#	23.98 ± 9.90§
6. VWD+VWF to 7.1 ± 1.7% of normal VWF:Ag	4	0.47 ± 0.35#	14.64 ± 9.32§

^*ARFI Time to Hemostasis is defined as that required to bleed 75% of the total detected area of hemorrhage.

^†Mean from two separate procedures on each dog. No additional plasma therapy was required in these dogs.

^#Mean Bleeding Rate comparisons 1 vs 2 p<0.111, 1 vs 3 p<0.520, 1 vs 4 p<0.492, 1 vs 5 p<0.00003, 1 vs 6 p = 0.523, 5 vs 6 p = 0.00024.

^§Time to Hemostasis comparisons 1 vs 2 p<0.00078, 1 vs 3 p<0.027, 1 vs 4 p<0.057, 2 vs 4 p<0.01, 1 vs 5 p = 0.166, 1 vs 6 p = 0.566, 5 vs 6 p = 0.137.